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home > people - current lab members > Peter Walde

Prof. Dr. Peter Walde

Institut für Polymere
HCI F 501
ETH ZURICH
Wolfgang-Pauli-Str. 10
CH-8093 Zürich
Tel: (+41) 44 6320473
Fax: (+41) 44 6321265
e-mail: walde@mat.ethz.ch


Curriculum vitae

1956
November 24, born at Martigny, Switzerland

1975-1979
Study in chemistry at the Swiss Federal Institute of Technology (ETH) in Zürich: Diploma as chemist ("Dipl. Chem. ETH")

1980-1983
Ph.D. studies in the group of Prof. Pier Luigi Luisi at the ETH in Zürich: Ph.D. in natural sciences ("Dr. sc. nat. ETH"). Dissertation on characterization of bee venom peptides and proteolytic enzymes of sunflower seeds

1983-1984
Postdoc in the group of Prof. P.L. Luisi at the ETH in Zürich. Work on a novel trypsin inhibitor of white mustard seeds

1984-1985
Postdoc in the group of Prof. Charmian J. O'Connor at the University of Auckland in New Zealand.(Fellowship of Auckland University). Work on the activity of a lipase from human milk.

1985-1986
Postdoc in the group of Prof. Junzo Sunamoto at the University of Nagasaki in Japan. (Fellowship of the Matsumae International Foundation of Tokai University, Tokyo). Work on bile salt effects on liposomes and study of lipase activity in the presence of liposomes.

1986-1988
1989-1991
"Assistent" and
"Oberassistent" in the group of Prof. P.L. Luisi at the ETH in Zürich.

1992
Habilitation at the division of chemistry of the ETH ("Privatdozent"). "Venia legendi" for ' Supramolecular Chemistry'.

1997 Received the title of professor from the ETH Zürich ("Titularprofessor")


Research interest

* - Self-reproducing micelles and vesicles
* - Reactivity and molecular recognition in liposomes
* - Transdermal drug delivery
* - Enzymes in reverse micelles and vesicles
* - Giant vesicles


List of publications

1981

Walde P., Jaeckle H., Luisi P.L., Dempsey C.J., Banks B.E.C.,
Biopolymers, 20, 373-385 (1981).
"Spectroscopic Investigations of Peptide 401 from Bee Venom."

1984

Walde P., Luisi P.L., Palmieri S.,
J. Agric. Food Chem., 32, 322-329 (1984).
"Proteolytic Activity in Sunflower Seeds (Helianthus annuus L.)."

1985

Menegatti E., Palmieri S., Walde P., Luisi P.L.,
J. Agric. Food. Chem., 33, 784-789 (1985).
"Isolation and Characterization of a Trypsin Inhibitor from White Mustard (Sinapis alba L.)."

1986

O'Connor C.J., Walde P., Wallace R.,
J. Pediatr. Gastroenterol. Nutr., 5, 622-629 (1986).
"Bile Salt Roles in Bile-Salt-Stimulated Lipase Activity."

O'Connor C.J., Longbottom J.R., Walde P.,
J. Pediatr. Gastroenterol. Nutr., 5, 630-637 (1986).
"Inactivation of Bile-Salt-Stimulated Human Milk Esterase. - Effect of Storage and Heat."

O'Connor C.J., Walde P.,
Langmuir, 2, 139-146 (1986).
"Interactions of Human Milk Lipase with Sodium Taurocholate and Other Surfactants."

O'Connor C.J., Walde P.,
J. Colloid. Interface Sci., 112, 488-496 (1986).
"The Effect of Proteins on Bile-Salt-Stimulated Human Milk Lipase Activity against 4-Nitrophenylacetate."

O'Connor C.J., Mitha A.S.H., Walde P.,
Aust. J. Chem., 39, 249-257 (1986).
"Hydrophobic Substrate Effects on the Esterase Activity of Bile-Salt Stimulated Human Milk Lipase. Hydrolysis of 4-Nitrophenyl Alkanoates and Alkyl 4-Nitrophenylbenzoates."

O'Connor C.J., Stockley I.C., Walde P.,
Aust. J. Chem., 39, 2037-2048 (1986).
"The Effect of Reversed Micelles and of Aerosol-OT Aqueous Micelles on the Esterase Activity of Bile-Salt-Stimulated Human Milk Lipase. Determination of Enzyme-Inhibitor Complex Dissociation Constants."

O'Connor C.J., Singh R.M.D., Walde P., Spedding D.J.,
J. Bioact. Compat. Polym., 1, 181-197 (1986).
"The Effect of pH on the Uptake of 35S(-II) by Wine Yeasts."

O'Connor C.J., Singh R.M.D., Walde P., Spedding D.J.,
J. Bioact. Compat. Polym., 1, 335-347 (1986).
"Effect of Temperature on the Uptake of 35S(-II) by Wine Yeasts."

O'Connor C.J., Singh R.M.D., Walde P., Spedding D.J.,
J. Plant Physiol., 125, 123-136 (1986).
"Uptake and Metabolism of Sulphides by Wine Yeasts."

1987

Walde P., Sunamoto J., O'Connor C.J.,
Biochim. Biophys. Acta, 905, 30-38 (1987).
"The Mechanism of Liposome Damage by Taurocholate."

Walde P., Sunamoto J., O'Connor C.J.,
Biochim. Biophys. Acta, 905, 39-47 (1987).
"Activity of Bile-Salt-Stimulated Human Milk Lipase in the Presence of Egg Lecithin Liposomes or Mixed Bile Salt/Lecithin Micelles."

1988

Walde P., Peng Q., Fadnavis N.W., Battistel E., Luisi P.L.,
Eur. J. Biochem., 173, 401-409 (1988).
"Structure and Activity of Trypsin in Reverse Micelles."

Magid L., Walde P., Zampieri G., Battistel E., Peng Q., Trotta E., Maestro M., Luisi P.L.,
Colloids and Surfaces, 30, 193-207 (1988).
"Research Report on Proteins in Reverse Micelles. Structural Aspects and Enzymology."

1989

Walde P., Luisi P.L.,
Biochemistry, 28, 3353-3360 (1989).
"A Contiunuous Assay for Lipases in Reverse Micelles Based on Fourier Transform Infrared Spectroscopy."

Nastruzzi C., Walde P., Menegatti E., Gambari R.,
Biochim. Biophys. Acta, 1013, 36-41 (1989).
"Differential Effects of Liposome-Entrapped Desferrioxamine on Proliferation and Erythroid Differentiation of Murine Erythroleukemic Friend Cells."

Walde P. in "Reactions in Compartmentalized Liquids" (Knoche W., Schomäcker R., editors), Springer-Verlag, Berlin, Heidelberg, pp. 11-19(1989).
"Lipases as Examples for Enzymes in Reverse Micelles."

1990 Walde P., J. Am. Oil Chem. Soc., 67, 110-115 (1990). "A Colorimetric Determination of Fatty Acids as a New Assay of Lipases in Reverse Micelles." Nastruzzi C., Gambari R., Menegatti E., Walde P., Luisi P.L., J. Pharm. Sci., 79, 672-677 (1990). "Tumor Cell Growth Inhibition by Liposome Encapsulated Aromatic Poly-amidines." Walde P., Giuliani A.M., Boicelli C.A., Luisi P.L., Chem. Phys. Lipids, 53, 265-288 (1990). "Phospholipid-Based Reverse Micelles." Bianucci M., Maestro M., Walde P., Chem. Phys., 141, 273-283 (1990). "Bell-shaped Curves of the Enzyme Activity in Reverse Micelles: A Simplified Model for Hydrolytic Reactions." Nastruzzi C., Walde P., Menegatti E., Gambari R., FEBS Lett., 259, 293-296 (1990). "Liposome-Associated Retinoic Acid: Increased "in vitro" Antiproliferative Effects on Neoplastic Cells." Han D., Walde P., Luisi P.L., Biocatalysis, 4, 153-161 (1990). "Dependence of Lipase Activity on Water Content and Enzyme Concentration in Reverse Micelles." Bachmann P.A., Walde P., Luisi P.L., Lang J., J. Am. Chem. Soc., 112, 8200-8201 (1990). "Self-replicating Reverse Micelles and Chemical Autopoiesis." Walde P., Luisi P.L., Biocatalysis, 3, 381-383 (1990). "Detection of Water in Lipase-catalyzed Reactions in Reverse Micelles as Studied by Infrared Spectroscopy."

1991 Walde P., Nastruzzi C., Food Chem., 39, 249-256 (1991). "Application of a New, Simple and Economic Colorimetric Method for the Determination of Non-esterified Fatty Acids in Vegetable Oils." Bru R., Walde P., Eur. J. Biochem., 199, 95-103 (1991). "Product Inhibition of-Chymotrypsin in Reverse Micelles." Mao Q., Walde P., Biochem. Biophys. Res. Commun., 178, 1105-1112 (1991). "Substrate Effects on the Enzymatic Activity of-Chymotrypsin in Reverse Micelles." Bachmann P.A., Walde P., Luisi P.L., Lang J., J. Am. Chem. Soc., 113, 8204-8209 (1991). "Self-replicating Micelles: an Extension to Aqueous Micelles and Enzymatically Driven Reactions in Reverse Micelles." Walde P., Luisi P.L., in GPF Monograph Volume 16, "Lipases: Structure, Mechanism and Genetic Engineering", (Alberghina R.D., Schmid,R.D., Verger R., eds.), Verlag Chemie, Weinheim, pp. 155-158 (1991). "Lipases in Reverse Micelles."

1992

Willimann H., Walde P., Luisi P.L., Gazzaniga A., Stroppolo F.,
J. Pharm. Sci., 81, 871-874 (1992).
"Lecithin Organogel as Matrix for Transdermal Transport of Drugs."

Maestro M., Walde P.,
J. Colloid Interface Sci., 154, 298-302 (1992). "Application of a Simple Diffusion Model for the Enzymatic Activity of-Chymotrypsin in Reverse Micelles."

Mao Q., Walde P., Luisi P.L.,
Eur. J. Biochem., 208, 165-170 (1992). "Kinetic Behaviour of-Chymotrypsin in Reverse Micelles.- A Stopped Flow Study."

Walde P., Mao Q., Bru R., Luisi P.L., Kuboi R.,
Pure & Appl. Chem., 64, 1771-1775 (1992).
"PH Artifacts in Reverse Micellar Enzymology.- A Warning."

Walde P., Dreher F.,
in "Tissue Cultures in Cosmetic Biotechnology"(R. Gambari, C. Nastruzzi, eds.), Alberto Nocenti, Italy, pp. 65-7 (1992).
"Microemulsion-based Phospholipid Gels for Percutaneous Absorption of Drugs."

1993

Walde P., Han D., Luisi P.L.,
Biochemistry, 32, 4029-4034 (1993).
"Spectroscopic and Kinetic Studies of Lipases Solubilized in Reverse Micelles."

Bru R., Walde P.,
Biochem. & Mol. Biol. Int., 31, 685-692 (1993).
"Catalytic Activity of Elastase in Reverse Micelles."

Haber J., Maslakiewicz P., Rodakiewicz-Nowak J., Walde P.,
Eur. J. Biochem., 217, 567-573 (1993).
"Activity and Spectroscopic Properties of Bovine Liver Catalase in AOT/isooctane Reverse Micelles."

Nastruzzi C., Esposito E., Menegatti E., Walde P.,
J. Appl. Cosmetol., 11, 77-91 (1993).
"Use and Stability of Liposomes in Dermatological Preparations."

Luisi P.L., Vonmont-Bachmann P.A., Fresta M., Walde P., Wehrli E.,
J. Liposome Res., 3, 631-638 (1993).
"Self-Reproduction of Micelles and Liposomes and the Transition to Life."

1994 O'Connor C.J., Cleverly D.R., Butler P.A.G., Walde P., J. Bioact. Compat. Polym., 9, 66-79 (1994). "Isolation and Characterization of Purified Bile Salt Stimulated Human Milk Lipase." Bonaccio S., Walde P., Luisi P.L., J. Phys. Chem., 98, 6661-6663 and 10376 (1994). "Liposomes Containing Purine and Pyrimidine Bases: Stable Unilamellar Liposomes from Phosphatidyl-nucleosides." Walde P., Goto A., Monnard P.-A., Wessicken M., Luisi P.L., J. Am. Chem. Soc., 116, 7541-7547 (1994). "Oparin's Reactions Revisited: Enzymatic Synthesis of Poly(adenylic acid) in Micelles and Self-Reproducing Vesicles." Vonmont-Bachmann P.A., Walde P., Luisi P.L.,J. Liposome Res., 4, 1135-1158 (1994). "Lipase-catalyzed Reactions in Vesicles as an Approach to Vesicle Self-Reproduction." Walde P., Wick R., Fresta M., Mangone A., Luisi P.L., J. Am. Chem. Soc., 116, 11649-11654 (1994). "Autopoietic Self-Reproduction of Fatty Acid Vesicles." Walde P., Bachmann P.A., Schmidli P.K., Luisi P.L., in "Advances in the Applications ofMembrane-Mimetic Chemistry." (Yen T.F., Gilbert R.,D., Fendler J. H., eds.), Plenum Press, New York, pp. 25-39 (1994). "Chemical Autopoiesis: Self-Replication of Micelles and Vesicles." Walde P. in "Self-Production of Supramolecular Structures. From Synthetic Structures to Models of Minimal Living Systems" (Fleischaker G.R., Colonna S., Luisi P.L., eds.), NATO Advanced Research Workshop, Acquafredda di Maratea, Italy, 12-16 September 1993, Kluwer Academic Publishers, Dordrecht, The Netherlands, pp. 209-216 (1994). "Self-Reproducing Vesicles." Bonaccio S., Cescato C., Walde P., Luisi P.L. in "Self-Production of Supramolecular Structures. From Synthetic Structures to Models of Minimal Living Systems" (Fleischaker G., Colonna S., Luisi P.L., eds.), NATO Advanced Research Workshop, Acquafredda di Maratea, Italy, 12-16 September 1993, Kluwer Academic Publishers, Dordrecht, The Netherlands, pp. 255-259 (1994). "Liposomes from Lipidonucleotides and from Lipidopeptides." Wick R., Walde P., Luisi P.L. in "Self-Production of Supramolecular Structures. From Synthetic Structures to Models of Minimal Living Systems" (Fleischaker G., Colonna S., Luisi P.L., eds.), NATO Advanced Research Workshop, Acquafredda di Maratea, Italy, 12-16, September 1993, Kluwer Academic Publishers, Dordrecht, The Netherlands, pp. 295-299 (1994). "Giant Vesicles." Luisi P.L., Walde P., Oberholzer T., Ber. Bunsenges. Phys. Chem., 98, 1160-1165 (1994) "Enzymatic RNA Synthesis in Self-Reproducing Vesicles: an Approach to the Construction of a Minimal Synthetic Cell."

1995 Wick R., Walde P., Luisi P.L., J. Am. Chem. Soc., 117, 1435-1436 (1995). "Autocatalytic Self-Reproduction of Giant Vesicles." Vaillo E., Walde P., Spichiger U. E., Analytical Methods and Instrumentation, 2, 145 - 153 (1995). "Development of a Micellar Biooptode Membrane for an Urea Sensor" Luisi P. L., Walde P. in "Conceptual Tools for Understanding Nature" (Costa G., Calcucci G., Giorgi M., eds.), World Scientific Co., Singapore, pp. 149-171 (1995). "Self-Reproducing Liposomes and Chemical Autopoiesis."

1996 Dreher F., Walde P., Luisi P.L., Elsner P., Skin Pharmacol. 9, 124-129 (1996). "Human Skin Irritation Studies of a Lecithin Microemulsion Gel and of Lecithin Liposomes." Wick R., Angelova M. I., Walde P., Luisi P. L., Chem. & Biol., 3, 105-111 (1996). "Microinjection into Giant Vesicles and Light Microscopy Investigation of Enzyme Mediated Vesicle Transformations." Dorovska-Taran V., Wick R., Walde P., Anal. Biochem. 240, 37-47 (1996). "A 1H-NMR Method for Investigating the Phospholipase D Catalyzed Hydrolysis of Phosphatidylcholine in Liposomes" Capitani D., Segre A.L., Dreher F., Walde P., Luisi P.L., J. Phys. Chem. 100, 15211-15217 (1996). “A Multinuclear NMR Investigation of Phosphatidylcholine Organogels.” Bonaccio S., Wessicken M., Berti D., Walde P., Luisi P.L., Langmuir 12, 4976-4978 (1996). “Relation Between the Molecular Structure of Phosphatidyl Nucleosides and the Morphology of their Supramolecular and Mesoscopic Aggregates.” Walde P., Current Opinion in Colloid & Interface Sci. 1, 638-644 (1996) "Enzymatic Reactions in Liposomes." Luisi P.L., Walde P., in "Handbook of Nonmedical Applications of Liposomes, Volume II: Models for Biological Phenomena" (Y. Barenholz, D.D. Lasic, eds.), CRC Press, Inc., Boca Raton, pp. 315-328 (1996) "Self-Reproducing Liposomes and Chemical Autopoiesis"

1997 Morigaki K., Dallavalle S., Walde P., Colonna S., Luisi P.L., J. Am. Chem. Soc. 119, 292-301 (1997). "Autopoietic Self-Reproduction of Chiral Fatty Acid Vesicles." Dreher F., Walde P., Walther P., Wehrli E., J., Control. Release 45, 131-140 (1997). "Interaction of a Lecithin Microemulsion Gel with Human Stratum Corneum and its Effect on Transdermal Transport." Walde P., Blöchliger E., Langmuir 13, 1668-1671 (1997). "Circular Dichroic Properties of Phosphatidylcholine Liposomes." Bonaccio S., Capitani D., Segre A.L., Walde P., Luisi P.L., Langmuir 13, 1952-1956 (1997). “Liposomes from Phosphatidyl Nucleosides: an NMR Investigation.” Cescato C., Walde P., Luisi P. L., Langmuir 13, 4480-4482 (1997). "Supramolecular Transformations of Vesicles from Amino Acid Based Double Chain Amphiphiles" Walde P., Wessicken M, Rädler U., Berclaz N., Conde-Frieboes K., Luisi P. L., J. Phys. Chem. B 101, 7390-7397 (1997). “Preparation and Characterization of Vesicles from Mono-n-alkyl Phosphates and -Phosphonates.” Kuboi R., Yoshimoto M., Walde P., Luisi P. L., Biotechnol. Prog. 13, 828-836 (1997). “Folding of Carbonic Anhydrase Assisted by 1-Palmitoyl-2-Oleoyl-sn-glycero-3-phosphocholine Liposomes.” Goto A., Hakamata H., Kuwahara Y., Goto R., Walde P., Luisi P. L., Imae T.,Progr. Colloid Polym. Sci. 106, 245-248 (1997). “Functional Nano-Structure of Aggregates Self-Organized on the Liquid/Solid Interface. Enzymatic Polymerization of ADP.”

1998 Walde P., Marzetta B., Biotechnol. Bioeng. 57, 216-219 (1998). "Bilayer Permeability Based Substrate Selectivity of an Enzyme in Liposomes." Bucher P., Fischer A., Luisi P. L., Oberholzer T., Walde P., Langmuir 14, 2712-2721 (1998). “Giant Vesicles as Biochemical Compartments: the Use of Microinjection Techniques.” Goto A., Goto R., Kuwahara Y., Hakamada H., Ibuki Y., Walde P., Luisi P. L., Imae T., Langmuir 14, 3454-3457 (1998). “Atomic Force Microscopy Observation of Poly(A) Grown on the Liquid/Solid Interface from Sodium Bis(2-ethylhexyl) Sulfosuccinate/Isooctane Reversed Micellar Solution.” Blöchliger E., Blocher M., Walde P., Luisi P. L., J. Phys. Chem. B. 102, 10383-10390 (1998). “Matrix Effect in the Size Distribution of Fatty Acid Vesicles.”

1999 Blocher M., Walde P., Dunn I. J., Biotechnol. Bioeng. 62, 36-43 (1999). “Modeling of Enzymatic Reactions in Vesicles: The Case of-Chymotrypsin.” Fritz M. G., Walde P., Seebach D., Macromolecules, 32, 574-580 (1999) “Oligoesters of (R)-3-Hydroxybutanoic Acid (OHB): Transmembrane Transport of Ca2+ Across Vesicle Bilayers.” Walde P., Blöchliger E., Morigaki K, Langmuir, 15, 2346-2350 (1999). “Circular Dichroism Properties of Phosphatidylcholine Micelles.” Yoshimoto M., Walde P., Umakoshi H., Kuboi R., Biotechnol. Prog. 15, 689-696 (1999). “Conformationally Changed Cytochrome c-mediated Fusion of Enzyme- and Substrate-containing Liposomes.” Blocher M., Liu D., Walde P., Luisi P. L., Macromolecules 32, 7332-7334 (1999). “Liposome-Assisted Selective Polycondensation of-Amino Acids and Peptides.” Lonchin S., Luisi P. L., Walde P., Robinson, B. H., J. Phys. Chem. B. 103, 10910-10916 (1999). “A Matrix Effect in Mixed Phospholipid/Fatty Acid Vesicle Formation” Luisi P. L., Walde P., Oberholzer T., Curr. Opinion in Colloid & Interface Sci. 4, 33-39 (1999). “Lipid Vesicles as Possible Intermediates in the Origin of Life.”

2000

Luisi P. L.,Walde P.,Blocher M., Liu D., Chimia 54, 52-53 (2000).
Research on the Origin of Life: Membrane-Assited Polycondensations of Amino Acids and Peptides
“Giant Vesicles”, Perspectives in Supramolecular Chemistry, Volume 6 (Luisi P. L., Walde P., eds.), John Wiley & Sons, Ltd, Chichester, 2000.

Fischer A., Luisi P. L., Oberholzer, T, Walde P.,
in “Giant Vesicles”, Perspectives in Supramolecular Chemistry, Volume 6 (Luisi P. L., Walde P., eds.), John Wiley & Sons, Ltd, Chichester, pp. 37-43 (2000).
Formation of Giant Vesicles from Different Kinds of Lipids Using the Electroformation Method.

Goto A., Suzuki A., Yoshioka H., Goto R, Imae T., Yamazaki K, Walde P.,
in “Giant Vesicles”, Perspectives in Supramolecular Chemistry, Volume 6 (Luisi P. L., Walde P., eds.), John Wiley & Sons, Ltd, Chichester, pp. 261-270 (2000).
Dynamic Aspects of Fatty Acid Vesicles: pH-induced Vesicle-Micelle Transition and Dilution-induced Formation of Giant Vesicles.

Walde P.,
in “Giant Vesicles”, Perspectives in Supramolecular Chemistry, Volume 6 (Luisi P. L., Walde P., eds.), John Wiley & Sons, Ltd, Chichester, pp. 297-311 (2000).

2001

Berclaz N., Müller M., Walde P., Luisi P. L.,
J. Phys. Chem B105, 1056-1064 (2001).
"Growth and Transformation of Vesicles Studied by Ferritin-Labelling and Cryo-Transmission Electron Microscopy"

Hitz T., Blocher M., Walde P., Luisi P. L.,
Macromolecules 34, 2443-2449 (2001).
"Stereoselective Aspects in the Condensation of Racemic NCA-Amino Acids in Presence and Absence of Liposomes"

Fukuda H., Goto A., Yoshioka H., Goto R., Morigaki K., Walde P.,
Langmuir 17, 4223-4231 (2001).
"An Electron Spin Resonance Study of the pH-Induced Transformation of Micelles to Vesicles in an Aqueous Oleic Acid/Oleate System"

Smith R. E., Burmaster S., Glaros A. G., Eick J. D., Walde P., Kostoryz E.L., Yourtee D. M.,
Biochim. Biophys. Acta 1550, 100-106 (2001).
"Aromatic Dental Monomers Affect the Activity of Cholesterol Esterase."

Schuler L., Walde P., Luisi P. L., van Gunsteren W. F.,
Eur. Biophys. J. 30, 330-343 (2001).
"Molecular Dynamics Simulation of n-Dodecylphosphate Aggregate Structures."

Walde P., Ichikawa, S.,
Biomol. Eng. 18, 143-177 (2001).
"Enzymes Inside Lipid Vesicles. Preparation , Reactivity and Applications."

2002

Treyer M., Walde P., Oberholzer T.,
Langmuir 18, 1043-1050 (2002)
"Permeability Enhancement of Lipid Vesicles to Nucleotides by Use of Sodium Cholate. Basic Studies and Application to an Enzyme-Catalyzed Reaction Occurring inside the Vesicles."
Morigaki K., Walde P. Langmuir, 18, 10509-10511 (2002) Giant Vesicle Formation from Oleic Acid/Sodium Oleate on Glass Surfaces Induced by Adsorbed Hydrocarbon Molecules

2003

Morigaki K., Walde P.,Misran M., Robinson B. H.
Colloid and Surfaces A: Physiocochem. Eng. Aspects 213, 37-44 (2003)
Thermodynamic and kinetic stability. Properties of micelles and vesicles formed by the decanoic acid/decanoate system

Yoshimoto M.,Wang S.,Fukunaga K.,Walde P.,Kuboi R., Nakao K.
Biotechnology and Bioengineering 81, No. 6, (2003)
Preparation and Characterization of Reactive and Stable Glucose Oxidase-Containing Liposomes Modulated with Detergent

Walde P.
Chimia, 57 (7-8), 471-474 (2003)
Pier Luigi Luisi retires from the ETH

Walde P.
ASP Encyclopedia of Nanoscience and Nanotechnology (2003), Ed. H. S. Nalwa, Vol. 9, 43-79
Preparation of Vesicles (Liposomes)

Kato, K.; Walde, P.; Mitsui, H.; Higashi, N.
Biotechnol. Bioeng. 84 (4), 415-423 (2003)
Enzymatic activity and stability of D-fructose dehydrogenase and sarcosine dehydrogenase immobilized onto giant vesicles.

Walde, P., Morigaki, K.
Self-Assembly 443-453 (2003)
Formation and transformation of fatty acid/soap vesicles

2004

Yoshimoto, M.; Wang, S. Q.; Fukunaga, K.; Treyer, M.; Walde, P.; Kuboi, R.; Nakao, K.
Biotechnol. Bioeng. 85 (2), 222-233 (2004)
Enhancement of apparent substrate selectivity of proteinase K encapsulated in liposomes through a cholate-induced alteration of the bilayer permeability.

Zumbuehl, A.; Jeannerat, D.; Martin, S. E.; Sohrmann, M.; Stano, P.; Vigassy, T.; Clark, D. D.; Hussey, S. L.; Peter, M.; Peterson, B. R.; Pretsch, E.; Walde, P.; Carreira, E. M.
Angew. Chem. Int. Ed. 43 (39), 5181-5185 (2004)
An Amphotericin B-Fluorescein Conjugate as a Powerful Probe for Biochemical Studies of the Membrane.

Zumbuehl, A.; Stano, P.; Herr, D.; Walde, P.; Carreira, E. M.
Org. Lett. 6 (21), 3683-3686 (2004)
Amphotericin B as a Potential Probe of the Physical State of Vesicle Membranes.

Seebach D., Namoto K., Mahajan Y.R., Bindschaedler P., Sustmann R., Kirsch M., Ryder N.S., Weiss M., Sauer M., Roth C., Werner S., Beer H.-D., Munding C., Walde P., Voser M.
Chemistry and Biodiversity 1 (1), 65-97 (2004)
Chemical and biological investigations of beta-oligoarginines.

Ichikawa, S., Walde, P.
Langmuir 20(3), 941-949 (2004)
Phospholipase D-Mediated Aggregation, Fusion, and Precipitation of Phospholipid Vesicles.

2005

Yoshimoto M., Wang S., Fukunaga K., Fournier D., Walde P., Kuboi R., Nakao K.
Biotechnology and Bioengineering 90(2), 231-238 (2005)
Novel immobilized liposomal glucose oxidase system using the channel protein OmpF and catalase

Namani T., Walde P.
Langmuir 21, 6210-6219 (2005)
From Decanoate Micelles to Decanoic Acid/Dodecylbenzenesulfonate Vesicles

Walde P. (editor)
Topics in Current Chemistry - Volume 259 (2005)
"Prebiotic Chemistry"

2006

Rogerson ML, Robinson BH, Bucak S, Walde P
Colloids and Surfaces B - Biointerfaces 48 (1), 24-34, (2006)
Kinetic studies of the interaction of fatty acids with phosphatidylcholine vesicles (liposomes)

Hitz T, Iten R, Gardiner J, Namoto K, Walde P, Seebach D
Biochemistry 45 (18), 5817-5829 (2006)
Interaction of alpha- and beta-oligoarginine-acids and amides with anionic lipid vesicles: A mechanistic and thermodynamic study

Walde P
Origins of Life and Evolution of Biospheres 36 (2), 109-150 (2006)
Surfactant assemblies and their various possible roles for the Origin(s) of Life

2007

Shimanouchi T, Walde P, Gardiner J, Mahajan YR, Seebach D, Thomae A, Krämer SD, Voser M, Kuboi R.
Biochim Biophys Acta. 2007, 1768(11):2726-36.
Permeation of a beta-heptapeptide derivative across phospholipid bilayers.

Yoshimoto M, Miyazaki Y, Umemoto A, Walde P, Kuboi R, Nakao K.
Langmuir 2007; 23(18):9416-22.
Phosphatidylcholine vesicle-mediated decomposition of hydrogen peroxide

Zumbuehl A, Stano P, Sohrmann M, Peter M, Walde P, Carreira EM.
Org Biomol Chem. 2007, 5(9):1339-42.
A novel strategy for bioconjugation: synthesis and preliminary evaluation with amphotericin B.

2008

Zepik H.H., Walde, P., Ishikawa T,
Angew Chem Int Ed Engl. 2008 - In press
Vesicle Formation from Reactive Surfactants

Zepik H.H., Walde P., Kostoryz E.L., Code J., Yourtee D.M.
Crit Rev Toxicol. 2008 , 38(1):1-11.
Lipid vesicles as membrane models for toxicological assessment of xenobiotics

Capone, S.; Walde, P.; Seebach, D.; Ishikawa, T.;Caputo, R.
Chemistry & Biodiversity 2008 , 5(1):16-30.
pH-sensitive vesicles containing a lipidic beta-amino acid with two hydrophobic chains

Zepik, H. H.; Walde, P.; Ishikawa, T.
Angew. Chem. Int. Ed. 2008 , 47:1323-1325.
Vesicle formation from reactive surfactants

Sugiura, S.; Kuroiwa, T.; Kagota, T.; Nakajima, M.; Sato, S.; Mukataka, S.; Walde, P.; Ichikawa, S. Langmuir 2008 , 24(9):4581-4588.
Novel method for obtaining homogeneous giant vesicles from a monodisperse water-in-oil emulsion prepared with a microfluidic device

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